Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells.
نویسندگان
چکیده
Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H(2)O(2)) in living systems. The chemoselective reaction of these boronate-protected probes with H(2)O(2) resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H(2)O(2) in RAW 264.7 macrophages using time-gated luminescent spectroscopy.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 40 شماره
صفحات -
تاریخ انتشار 2010